Karyopharm’s SINE compounds function by binding with and inhibiting the nuclear export protein XPO1 (or CRM1). In addition to single-agent and combination activity against a variety of human cancers, SINE compounds have also shown biological activity in models of neurodegeneration, inflammation, autoimmune disease, certain viruses and wound-healing. Karyopharm, which was founded by Dr. Sharon Shacham, currently has several investigational programs in clinical or preclinical development. For more information, please visit www.karyopharm.com . Forward-Looking Statements This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding the therapeutic potential of and potential clinical development plans for Karyopharm’s drug candidates, including the timing of initiation of certain trials and of the reporting of data from such trials. Such statements are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from the Company’s current expectations. For example, there can be no guarantee that any of Karyopharm’s SINE compounds, including selinexor (KPT-330), will successfully complete necessary preclinical and clinical development phases or that development of any of Karyopharm’s drug candidates will continue. Further, there can be no guarantee that any positive developments in Karyopharm’s drug candidate portfolio will result in stock price appreciation. Management’s expectations and, therefore, any forward-looking statements in this press release could also be affected by risks and uncertainties relating to a number of other factors, including the following: Karyopharm’s results of clinical trials and preclinical studies, including subsequent analysis of existing data and new data received from ongoing and future studies; the content and timing of decisions made by the U.S.
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plural feet play \ˈfēt\ also foot 2 : an invertebrate organ of locomotion or attachment; especially : a ventral muscular surface or process of a mollusc 3 : any of various units of length based on the length of the human foot; especially : a unit equal to 1⁄3 garden and comprising 12 inches plural foot used between a number and a noun plural feet or foot used between a number and an adjective — see weight table 4 : the basic unit of verse meter consisting of any of various fixed combinations or groups of stressed and unstressed or long and short syllables 5 a : motion or power of walking or running : step b : speed, swiftness 6 : something resembling a foot in position or use: as a : the lower end of the leg of a chair or table b 1 : the basal portion of the sporophyte in mosses 2 : a specialized outgrowth by which the embryonic sporophyte especially of many bryophytes absorbs nourishment from the gametophyte c : a piece on a sewing machine that presses the cloth against the feed 7 foot plural chiefly British : infantry 8 : the lower edge as of a sail 9 : the lowest part : bottom 10 a : the end that is lower or opposite the head b : the part as of a stocking that covers the foot 11 foots plural but sing or plural in constr : material deposited especially in ageing or refining : dregs
But Ferentz said he expects VandeBergs teammates to make up for his absence. This is hardly a crisis stage. browse around this web-siteI mean, were all really sorry Matt got hurt. Dont get me wrong. Im not minimizing that. But hey, were going to play, Ferentz said. useful siteIowa also have some options in the passing game beyond its receivers. Tight end George Kittle has blossomed from a blocker capable of making the occasional big play to a crucial piece of the offense. He has 191 yards receiving, including a 36-yard TD catch in last weeks ugly 14-7 win at Rutgers.
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